mTOR inhibitor-8

SKU: orb1693847

Description

mTOR inhibitor-8 is a potent, cell-permeable compound that selectively targets the mTOR kinase, demonstrating robust antiviral and antitumor activity. It effectively induces autophagy and inhibits the proliferation of A549 non-small cell lung cancer cells in vitro, serving as a valuable tool for oncology and autophagy research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2489196-70-3
• MW: 446.95
• Purity: 98.11%
• Formula: C₂₄H₁₉ClN₄OS
• SMILES: COc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccncc1)c1ccc(Cl)cc1
• Target: Autophagy,mTOR
• Solubility: 10% DMSO+90% Saline:2 mg/mL (4.47 mM);DMSO:20 mg/mL (44.75 mM)

Bioactivity

• In Vivo:
  In vivo, mTOR inhibitor-8 effectively inhibits tumor growth at concentrations of 25 and 50 μM for a duration of 6 days, without adversely affecting angiogenesis in the normal chick chorioallantoic membrane .
• In Vitro:
  mTOR inhibitor-8 (Compound 5e; 0.1-10 μM) suppresses the growth of A549 cells in a dose-dependent manner after 24 and 48 hours of treatment. At a concentration of 10 μM, mTOR inhibitor-8 induces autophagy in an mTOR-dependent and time-dependent manner (3-24 hours), increasing LC3B-II levels and reducing the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, mTOR, mTOR inhibitor 8, mTOR inhibitor8, mTOR inhibitor-8, mTOR-IN-8

Compound Identifiers

PubChem CID

154573769