MTHFD2-IN-7

SKU: orb3211498

Description

MTHFD2-IN-7 is an orally active and selective inhibitor of MTHFD2, exhibiting IC50 values of 0.038 μM for human-derived hMTHFD1 and 7.44 μM for hMTHFD2. It operates by binding to the substrate binding site of MTHFD2 while maintaining interaction with NAD+. Validated by TSA and DARTS experiments, MTHFD2-IN-7 effectively binds its target protein and demonstrates Caco-2 permeability and liver microsomal metabolic stability. In mice, it shows favorable pharmacokinetic properties. Furthermore, MTHFD2-IN-7 significantly inhibits cancer cell proliferation and reduces tumor size, making it a promising small molecule tool for acute myeloid leukemia research.

Key Properties

• Target: Dehydrogenase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dehydrogenase