MT189

SKU: orb1689814

Description

MT189 (Antiproliferative agent-14) is a potent small molecule inhibitor of tubulin polymerization with an IC50 of 3.41 µM. It exhibits excellent antiproliferative activity by arresting the cell cycle at the G2/M phase, making it a useful research tool for studying mitosis and cancer cell biology in vitro.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1885900-35-5
• MW: 363.38
• Purity: 98.67% (May vary between batches)
• Formula: C₂₁H₁₈FN₃O₂
• SMILES: COc1ccc(CNc2c(nc3ccc(F)cn23)-c2ccccc2O)cc1
• Target: Microtubule Associated
• Solubility: DMSO:90 mg/mL (247.67 mM)

Bioactivity

• In Vitro:
  MT189 shows antiproliferative activity against HeLa cell (IC50=13 nM). Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antiproliferative agent-14, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, MT189, MT-189, MT 189

Compound Identifiers

PubChem CID

86280647