MT-802

SKU: orb1308002

Description

MT-802 is a potent PROTAC-based BTK degrader with a DC50 of 1 nM. It is a research tool for investigating Bruton's tyrosine kinase (BTK) biology and has shown potential in preclinical studies targeting C481S mutant chronic lymphocytic leukemia (CLL) in cellular models.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2231744-29-7
• MW: 787.82
• Purity: 97.00% (May vary between batches)
• Formula: C₄₁H₄₁N₉O₈
• SMILES: NC1=C2C(=NN(C2=NC=N1)C3CCN(CCOCCOCC(NC=4C=C5C(=CC4)C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=O)CC3)C7=CC=C(OC8=CC=CC=C8)C=C7
• Target: PROTACs,BTK
• Solubility: DMSO:135 mg/mL (171.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.08 mM)

Bioactivity

• Target IC50:
  BTK:1 nM(DC50)
• In Vitro:
  MT-802 degrades BTK (DC50: 9.1 nM). The maximal degradation was observed by 250 nM.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MT802, MT-802, MT 802, Inhibitor, Bruton tyrosine kinase, Btk, BTK, PROTAC, PROTACs

Compound Identifiers

PubChem CID

138108326