MSN-125

SKU: orb1706941

Description

MSN-125 is a cell-permeable small molecule inhibitor of Bax/Bak oligomerization, thereby blocking mitochondrial outer membrane permeabilization (MOMP) and apoptosis. With an IC50 of 4 µM for MOMP inhibition, it has demonstrated protective effects against apoptotic cell death in HCT-116 cells, BMK cells, and primary cortical neurons, including in models of glutamate excitotoxicity.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1592908-16-1
• MW: 688.61
• Formula: C₃₆H₃₈BrN₃O₆
• SMILES: COCCOCOc1ccc2[C@@H]([C@@H](CN)Oc2c1)N(Cc1ccc(Br)cc1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
• Target: Apoptosis,Bcl-2 Family,Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146014431