MSDC-0602K

SKU: orb1691824

Description

MSDC-0602K (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione and mitochondrial pyruvate carrier (MPC) modulator. It functions as an insulin sensitizer and is used in research on metabolic diseases, including non-alcoholic fatty liver disease (NAFLD), insulin resistance, and hepatic inflammation, as demonstrated in murine in vivo studies.

Research Area

Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 1314533-27-1
• MW: 409.5
• Purity: 99.89%
• Formula: C₁₉H₁₆KNO₅S
• SMILES: COC1=CC=CC(=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)[N-]C(=O)S3.[K+]
• Target: IGF-1R,PPAR
• Solubility: DMSO:50 mg/mL (122.1 mM)

Bioactivity

• Target IC50:
  PPARγ:18.25 μM
• In Vivo:
  Diabetic db/db and MS-NASH mice are treated with MSDC-0602K via oral gavage, Liraglutide via s.c. injection, or a combination of MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis. Animal Model: Five-week-old Male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice. Dosage: 30 mg/kg MSDC-0602K and 0.2 mg/kg Liraglutide. Administration: MSDC-0602K gavage daily, Liraglutide s.c. every Other day, or combined MSDC-0602K + Liraglutide. Result: MSDC-0602K alone corrected glycemia and reduced insulinemia, whil the combination with Liraglutide significantly improved glucose tolerance and liver histolog.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azemiglitazone potassium, MSDC-0602K, PPARγ

Compound Identifiers

PubChem CID

87355566