MSDC 0602

SKU: orb1221589

Description

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).

Key Properties

• CAS Number: 1133819-87-0
• MW: 371.4
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₇NO₅S
• SMILES: COc1cccc(c1)C(=O)COc3ccc(CC2SC(=O)NC2=O)cc3
• Target: mTOR
• Solubility: DMSO : 125 mg/mL 336.56 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: HTF-C diet feeding C57BL6/J mice. Dosage: 331 ppm MSDC-0602 potassium salt (2-5 μM MSDC-0602 in blood). Administration: oral administration for 12 weeks (after 4 weeks of HTF-C diet) or 3 weeks (16 weeks after HTF-C diet). Result: Induced weight loss, decreased concentrations of plasma ALT and AST and stellate cell activation. Animal model: HTF-C diet feeding LS-Mpc2-/-C57BL6/J mice. Dosage: 331 ppm MSDC-0602 potassium salt (2-5 μM MSDC-0602 in blood). Administration: oral administration for 12 weeks (after 4 weeks of HTF-C diet). Result: Induced weight loss, suppressed stellate cell activation.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MSDC-0602 | MSDC0602

Quick Database Links

Gene Symbol

mTOR