MSDC 0160

SKU: orb1305270

Description

MSDC 0160

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 146062-49-9
• MW: 370.42
• Purity: 99.45%
• Formula: C₁₉H₁₈N₂O₄S
• SMILES: CCc1ccc(nc1)C(=O)COc1ccc(CC2SC(=O)NC2=O)cc1
• Target: IGF-1R,Mitochondrial Metabolism
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM);DMSO:37 mg/mL (99.89 mM)

Bioactivity

• In Vivo:
  Within the insulin and IGF-1 signaling pathways, MSDC-0160 reduces resistance and restores IGF-1-induced phosphorylation of AKt and GSK-3. When used in conjunction with IGF-1 and 8 mM glucose, MSDC-0160 boosts the expression of specific genes within β-cells, including insulin, pdx1, nkx6.1, and nkx2.2, while maintaining insulin content without affecting glucose-induced insulin secretion. Additionally, MSDC-0160 promotes the differentiation of human β-cells and decreases the expression of apoptosis markers.
• In Vitro:
  In the KKAy mouse model of diabetes, MSDC-0160 (100 mg/kg, p.o.) significantly enhanced insulin sensitivity by substantially reducing the levels of insulin and glucose in the circulatory system.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAY10415, CAY-10415, CAY 10415, Alzheimer, carrier, antidiabetic, mitochondrial, Mitochondrial Metabolism, MitochondrialMetabolism, Mitoglitazone, neuroprotective, pyruvate, mTOT, MSDC 0160, MSDC0160, MSDC-0160, inhibit, MPC, insulin, Insulin Receptor, Inhibitor, IGF1R, sensitizer, thiazolidinedione

Compound Identifiers

PubChem CID

10429242