MSC778

SKU: orb3173123

Description

MSC778 is a selective and orally active inhibitor of flap endonuclease 1 (FEN1), with an IC50 of 3 nM and a KD of 2.9 nM. It exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively targets BRCA2-deficient cells and enhances the tumor-stalling activity of Niraparib in BRCA2 KO DLD-1 mouse xenografts. It is applicable in colorectal cancer research.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 3098173-17-9
• MW: 441.87
• Formula: C₂₂H₂₀ClN₃O₅
• SMILES: O=C1C=2N(C[C@@]3(N1CCOC3)[H])N=C(O[C@@H](C)C4=CC5=C(C=C4)C=CC(Cl)=C5)C(=O)C2O
• Target: FLAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FLAP