MSC2360844

SKU: orb1309386

Description

MSC2360844 is a potent and selective oral inhibitor of PI3Kδ, exhibiting an IC50 of 145 nM. It is a valuable research tool for studying B-cell malignancies and inflammatory diseases in both cellular assays and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1305267-37-1
• MW: 526.58
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₂₇FN₄O₅S
• SMILES: Fc1cccc2-c3c(CS(=O)(=O)c12)c(nn3-c1ccc(CN2CCOCC2)cc1)C(=O)N1CCOCC1
• Target: PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (9.5 mM);DMSO:90 mg/mL (170.91 mM)

Bioactivity

• Target IC50:
  PI3Kδ:145 nM
• In Vivo:
  in a murine SLE model，MSC2360844 ameliorates disease manifestations .
• In Vitro:
  MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MSC 2360844, MSC2360844, MSC-2360844, inhibit, functions, Inhibitor, cells, PI3K, PI3Kδ, Phosphoinositide 3-kinase, primary, proliferation, SLE-prone

Compound Identifiers

PubChem CID

66580799