MS9427 TFA

SKU: orb1982768

Description

MS9427 TFA is a potent and selective PROTAC degrader of mutant EGFR (L858R), with high affinity for both wild-type (Kd=7.1 nM) and mutant (Kd=4.3 nM) forms. It induces degradation via UPS and autophagy pathways, demonstrating efficacy in inhibiting NSCLC cell proliferation in vitro, supporting its use in targeted cancer therapy research.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 1107.5
• Formula: C₅₀H₅₉ClF₄N₈O₁₄
• Target: EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,PROTACs