MS37452

SKU: orb1306209

Description

MS37452 is a small molecule that competitively inhibits the CBX7 chromodomain from binding to the H3K27me3 histone mark with a Ki of 43 µM. This inhibitor is a valuable chemical probe for studying Polycomb repressive complex function in epigenetics, cancer research, and stem cell biology, applicable in both in vitro and cellular assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 423748-02-1
• MW: 398.45
• Purity: 99.79% (May vary between batches)
• Formula: C₂₂H₂₆N₂O₅
• SMILES: COc1cccc(C(=O)N2CCN(CC2)C(=O)COc2cccc(C)c2)c1OC
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM);DMSO:60 mg/mL (150.58 mM)

Bioactivity

• Target IC50:
  CBX7:43 µM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p16/CDKN2A, transcription, CBX7, CBX7 chromodomain, derepress, anticancer, inhibit, Inhibitor, MS 37452, MS37452, MS-37452, INK4A/ARF, Histone Methyltransferase, HistoneMethyltransferase, H3K27me3

Compound Identifiers

PubChem CID

1072048