MS31 trihydrochloride (2366264-12-0 free base)

SKU: orb1309388

Description

MS31 trihydrochloride (free base CAS 2366264-12-0) is a potent and selective fragment-like inhibitor targeting the methyllysine reader protein SPIN1. It serves as a valuable chemical probe for investigating epigenetic signaling in cancer research and has demonstrated utility in both in vitro binding assays and cellular functional studies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2748239-18-9
• MW: 450.83
• Purity: 99.88% (May vary between batches)
• Formula: C₂₀H₃₀Cl₃N₃O₂
• SMILES: NCC1=C(C(OCCCN2CC3=C(C2)C=CC=C3)=CC(CN)=C1)OC.[H]Cl.[H]Cl.[H]Cl
• Target: Epigenetic Reader Domain
• Solubility: DMSO:60 mg/mL (133.09 mM)

Bioactivity

• Target IC50:
  SPIN1:(kd)91 nM |SPIN1:77 nM |SPIN1:243 nM
• In Vitro:
  MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2366264-12-0, 2366264-12-0 free base, Epigenetic Reader Domain, EpigeneticReaderDomain, MS31, MS-31, MS31 Trihydrochloride, MS31 trihydrochloride, MS-31 Trihydrochloride, MS31 trihydrochloride (2366264 12 0 free base), MS31 trihydrochloride (2366264120 free base), MS-31 trihydrochloride (2366264-12-0 free base), MS 31, MS 31 Trihydrochloride, spindlin 1 (SPIN1)

Compound Identifiers

PubChem CID

146014434