MS21

SKU: orb1690956

Description

MS21 is a selective AKT degrader that potently inhibits the growth of cancer cells harboring PI3K/PTEN pathway mutations while maintaining wild-type KRAS and BRAF. It is a valuable research tool for studying targeted protein degradation and AKT-dependent signaling in both in vitro and in vivo models of oncogenesis.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2376137-05-0
• MW: 1107.86
• Formula: C₅₈H₇₉ClN₁₂O₆S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CC[C@H](NC(=O)C3(N)CCN(CC3)c3ncnc4[nH]ccc34)c3ccc(Cl)cc3)CC2)C(C)(C)C)cc1
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155410583