MS182

SKU: orb2665462

Description

MS182 (compound 11) is an Acetylation Targeting Chimera (AceTAC) that recruits p300/CBP to mutant p53 Y220C, inducing its site-specific acetylation at K382 with an ACE50 of 1.52 µM. It exhibits anti-proliferative activity in cancer cell lines and demonstrates bioavailability in mice, supporting its use in targeted protein acetylation and oncology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 3034773-62-8
• MW: 1014.26
• Formula: C₅₇H₆₈FN₇O₇S
• SMILES: O=C(NCCOC1=CC=C(C=C1F)CCC2=NC=3C=C(C=CC3N2CCN4CCOCC4)C=5C(=NOC5C)C)CCOCCOCCOCCNCC=6C=CC7=C(C6)C=8C=CC(=CC8N7CC)C=9SC=C(C9)C
• Target: MDM-2/p53

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171506709