MS143

SKU: orb1983053

Description

MS143 is a potent and selective AKT degrader with a DC50 of 46 nM in PC3 cells. It induces targeted protein degradation via the ubiquitin-proteasome system, suppressing cancer cell proliferation in vitro. This molecule is a valuable chemical probe for studying AKT-dependent signaling pathways in oncology research.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2376137-41-4
• MW: 1121.87
• Formula: C₅₉H₈₁ClN₁₂O₆S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)N2CCN(CC[C@H](NC(=O)C3(N)CCN(CC3)c3ncnc4[nH]ccc34)c3ccc(Cl)cc3)CC2)C(C)(C)C)cc1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155410582