MS105

SKU: orb3027835

Description

MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 2408339-39-7
• MW: 1072.30
• Formula: C₅₆H₇₀FN₁₃O₆S
• SMILES: N(C=1C=2N(C(=CN2)C=3C=NNC3)C=C(N1)C4CC4)C5=C(F)C=C(C(=O)N6CCN(CC(NCCCCCCCCC(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)=O)CC6)C=C5
• Target: Apoptosis,Tyrosinase,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Tyrosinase,PROTACs