MS023 dihydrochloride

SKU: orb1688700

Description

MS023 dihydrochloride is a potent and selective cytosolic inhibitor of type I PRMTs (PRMT1, 3, 4, 6, 8). It exhibits antitumor activity and has been used in breast cancer research, where in vitro studies show it can increase the proliferative capacity of muscle stem cells (MuSCs).

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1992047-64-9
• MW: 360.32
• Purity: 99.52%
• Formula: C₁₇H₂₇Cl₂N₃O
• SMILES: Cl.Cl.CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
• Target: Histone Methyltransferase
• Solubility: DMSO:100 mg/mL (277.53 mM);H2O:20 mg/mL (55.51 mM)

Bioactivity

• In Vivo:
  In NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells, combinatorial treatment with MS023 dihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, i.g.) for 4 weeks extended the survival of leukemic mice compared to single treatments.
• In Vitro:
  MS023 dihydrochloride (1-1000 nM) effectively and concentration-dependently reduces PRMT1 methyltransferase activity in MCF7 cells.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MS023 2HCl, HistoneMethyltransferase, Histone Methyltransferase, PRMT1, PRMT3, PRMT4, PRMT6, PRMT8

Compound Identifiers

PubChem CID

121513886