MS-8709

SKU: orb2815252

Description

MS-8709 is a potent and selective PROTAC degrader of G9a/GLP (EHMT2/EHMT1) with DC50 values of 274 nM and 260 nM, respectively. It induces target degradation via the UPS and demonstrates superior anti-proliferative activity in prostate cancer, leukemia, and lung cancer cell models compared to inhibitor UNC0642, supported by favorable murine PK for in vivo studies.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3060730-06-2
• MW: 1200.57
• Formula: C₆₄H₉₅F₂N₁₁O₇S
• SMILES: N(C=1C2=C(N=C(N1)N3CCC(F)(F)CC3)C=C(OCCCN4CCCC4)C(OC)=C2)C5CCN(CCCC(NCCCCCCCCCCCC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)[C@@](C)(C)C)=O)=O)CC5
• Target: PROTACs,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171038121