MS-177

SKU: orb1739709

Description

MS-177 is a PROTAC-based EZH2 degrader that inhibits leukemia and multiple myeloma cell growth by inducing apoptosis and cell cycle arrest. It degrades both classical and non-classical EZH2 complexes, modulating pathways like WNT/β-catenin and activating immune-responsive genes, applicable for in vitro and in vivo cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2225938-86-1
• MW: 914.02
• Formula: C₄₈H₅₅N₁₁O₈
• SMILES: O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(CCNC(=O)CCOCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5
• Target: Apoptosis,Histone Methyltransferase,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139413605