MRZ 2-514

SKU: orb1309389

Description

MRZ 2-514 is a selective antagonist of the strychnine-insensitive glycineB site on the NMDA receptor, exhibiting a Ki of 33 μM. This compound is utilized in neuroscience research to investigate NMDA receptor function and glutamatergic signaling in both cellular and animal models of neurological conditions.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 202808-11-5
• MW: 308.09
• Purity: 98.46%
• Formula: C₁₁H₆BrN₃O₃
• SMILES: [O-][n+]1c2ccc(Br)cc2cc2c1c(=O)[nH][nH]c2=O
• Target: NMDAR,iGluR
• Solubility: DMSO:18.33 mg/mL (59.5 mM)

Bioactivity

• Target IC50:
  AMPA:72.7 μM|NMDA:33 μM (Ki)
• In Vivo:
  In mice, MRZ 2-514 has anticonvulsive action in the MES model, and the effect is prolonged by probenecid.
• In Vitro:
  MRZ 2-514 against peak AMPA-induced currents with IC50 values of 72.7 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMDA, inhibit, Ionotropic glutamate receptors, MRZ 2 514, MRZ 2514, MRZ 2-514, Inhibitor, iGluR, 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

Compound Identifiers

PubChem CID

9801704