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MRTX849-amide-C4-(o)-carborane

SKU: orb3211206

Description

MRTX849-amide-C4-(o)-carborane is a carborane-HyT conjugate that acts as a KRASG12C inhibitor, showing mutation selectivity for cells expressing KRASG12C. Exhibiting low inherent cytotoxicity in cancer cells, MRTX849-amide-C4-(o)-carborane covalently binds to Cys12 of KRASG12C, recruits Hsp70, promotes ubiquitination, and induces proteasome-dependent degradation of the target protein. This compound inhibits activity in the downstream ERK signaling pathway and induces apoptosis signaling in cancer cells. MRTX849-amide-C4-(o)-carborane is relevant for research on KRASG12C-positive cancers.

Images & Validation

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MRTX849-amide-C4-(o)-carborane

Key Properties

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TargetRas,CDK,PARP,Apoptosis,Caspase

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quick Database Links

Gene Symbol
Ras,CDK,PARP,Apoptosis,Caspase

Protocol Information

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