MRT68921 dihydrochloride

SKU: orb1298334

Description

MRT68921 dihydrochloride is a potent and selective dual inhibitor of the autophagy-initiating kinases ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. This compound is a valuable chemical probe for investigating autophagy mechanisms in both cellular and in vivo models of cancer and neurodegenerative disease research.

Research Area

Cell Biology

Key Properties

• CAS Number: 2080306-21-2
• MW: 507.499
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₃₆Cl₂N₆O
• SMILES: Cl.Cl.CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
• Target: Autophagy
• Solubility: H2O:33.33 mg/mL (65.68 mM);DMSO:2 mg/mL (3.94 mM)

Bioactivity

• Target IC50:
  ULK2:1.1 nM|ULK1:2.9 nM
• In Vitro:
  MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells. MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm). Autophagy-inhibiting capacity of the compounds is specifically through ULK1. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MRT 68921, MRT 68921 Dihydrochloride, MRT68921, MRT-68921, MRT68921 dihydrochloride, MRT68921 Dihydrochloride, MRT-68921 dihydrochloride, MRT-68921 Dihydrochloride, inhibit, Unc-51 like kinase, ULK, ULK2, ULK1

Compound Identifiers

PubChem CID

124201611