MRT67307 HCl (1190378-57-4(free base))

SKU: orb1302039

Description

MRT67307 is a potent and selective small molecule inhibitor targeting TBK1, IKKε, MARK1-4, and NUAK1 kinases. It is widely used in biochemical and cellular research to investigate innate immunity, autophagy, and cell polarity pathways in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• MW: 501.07
• Purity: 98.52% (May vary between batches)
• Formula: C₂₆H₃₇ClN₆O₂
• SMILES: Cl.O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
• Target: AMPK,Autophagy,IκB/IKK
• Solubility: H2O:10 mg/mL (19.96 mM);DMSO:50 mg/mL (99.79 mM)

Bioactivity

• Target IC50:
  MARK1-4:27-52nM|TBK1:19nM|IKKε:160nM|NUAK1:230 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TBK1, ULK1, ULK2, IkB, IkB/IKK, IKKϵ, IKK, NUAK1, IκB, MRT67307 HCl (1190378574(free base)), MRT-67307 HCl (1190378-57-4(free base)), MRT67307 HCl (1190378-57-4(free base)), MRT67307 HCl (1190378 57 4(free base))

Compound Identifiers

PubChem CID

129896717