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MRT-92

SKU: orb2665575

Description

MRT-92 is a potent Smoothened (Smo) antagonist with a Ki of 0.7 nM, inhibiting the Hedgehog pathway. It suppresses cerebellar granule cell proliferation (IC50=0.4 nM) and is used in research models for cerebellar gliomas, including in vitro and in vivo studies.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1428315-82-5
MW566.65
FormulaC33H34N4O5
SMILESO=C(NC(=N)NC1=CC=C(C(=C1)NC(=O)C2=CC=C(C=C2)CCC=3C=CC=CC3)C)C4=CC(OC)=C(OC)C(OC)=C4
TargetHedgehog/Smoothened,Smo

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information