MRT-14

SKU: orb1298037

Description

MRT-14 is a potent and selective antagonist of Smoothened (Smo), effectively inhibiting the Hedgehog (Hh) signaling pathway. It is a valuable research tool for studying Hh-driven cancers, suitable for both in vitro cellular assays and in vivo preclinical models of malignancies such as medulloblastoma and basal cell carcinoma.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1263131-83-4
• MW: 448.47
• Purity: 99.54% (May vary between batches)
• Formula: C₂₄H₂₄N₄O₅
• SMILES: COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1cccc(NC(=O)c2ccccc2)c1
• Target: Smo
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.46 mM);DMSO:50 mg/mL (111.49 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, Hedgehog, inhibit, Inhibitor, MRT 14, MRT14, MRT-14, Smoothened, Smo

Compound Identifiers

PubChem CID

136210502