MRS 1754

SKU: orb1308009

Description

MRS 1754 is a potent and selective A2B adenosine receptor antagonist radioligand, exhibiting minimal affinity for human and rat A1 and A3 receptor subtypes. It is a valuable tool for investigating A2B receptor function in both in vitro binding assays and in vivo models of inflammation, diabetes, and cancer.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 264622-58-4
• MW: 486.52
• Purity: 99.30% (May vary between batches)
• Formula: C₂₆H₂₆N₆O₄
• SMILES: CCCn1c2[nH]c(nc2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)Nc2ccc(cc2)C#N)cc1
• Target: Adenosine Receptor
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  A2B:1.45±0.21 nM(Ki, human)
• In Vitro:
  The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM. The most effective displacer of [3H]MRS 1754 binding is MRS 1754. .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P1 receptor, A2B, A2B Adenosine Receptor, Adenosine Receptor, AdenosineReceptor, inhibit, MRS 1754, MRS1754, MRS-1754, Inhibitor

Compound Identifiers

PubChem CID

6603931