MRK003

SKU: orb1740500

Description

MRK003 is a γ-secretase inhibitor demonstrating potent preclinical activity against multiple myeloma and non-Hodgkin's lymphoma cell lines and patient samples. It induces caspase-dependent apoptosis, modulates key proteins like Notch, c-Myc, and Bcl-2 family members, and shows crosstalk with the PI3K/Akt pathway, supporting its use in oncology research for in vitro mechanism of action studies.

Research Area

Cell Biology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 623165-93-5
• MW: 551.59
• Formula: C₂₅H₃₁F₆N₃O₂S
• SMILES: C(C(F)(F)F)N1C[C@@]2([C@]3(CC=4C(C[C@@]2(CC3)[H])=CC=C(/C=C/CN5CCC(C(F)(F)F)CC5)C4)[H])NS1(=O)=O
• Target: Apoptosis,Others,Gamma-secretase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

15953832