MRIA9

SKU: orb1693355

Description

MRIA9 is a potent ATP-competitive inhibitor of pan-Salt-Inducible Kinases (SIK1/2/3) and PAK2/3. It demonstrates potent activity in vitro with IC50 values of 516 nM, 180 nM, and 127 nM against SIK1, SIK2, and SIK3, respectively. This tool compound is valuable for probing SIK signaling in cellular and in vivo models of immunology and cancer.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2750707-05-0
• MW: 496.92
• Formula: C₂₄H₂₂ClFN₆O₃
• SMILES: C(N1C=2C(C=C(C1=O)C3=C(Cl)C=C(C=C3)C4=C(F)C=CC=N4)=CN=C(NC)N2)[C@@H]5OC[C@@H](N)CO5
• Target: SIK,Apoptosis,PAK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162642759