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MRGPRX4 modulator-3

SKU: orb3173216

Description

MRGPRX4 modulator-3 (Compound 1C) is an allosteric negative modulator of MAS-related G-protein coupled receptor X4 (MRGPRX4). It significantly inhibits the activation response induced by Nateglinide (an orthosteric agonist), with an IC50 of 337 nM. MRGPRX4 modulator-3 is applicable in studies related to chronic itching, particularly cholestatic pruritus, and pain.

Images & Validation

Key Properties

TargetMRGPR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information