MPI_5a

SKU: orb1308015

Description

MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM) with minimal activity against other HDAC isoforms. It effectively reduces cellular acyl-tubulin levels (IC50=210 nM), making it a valuable chemical probe for studying HDAC6 biology in cancer, neurodegeneration, and other research areas both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1259296-46-2
• MW: 299.32
• Purity: 99.62%
• Formula: C₁₆H₁₇N₃O₃
• SMILES: C(=O)(N1CC=2C(=CC(C(NO)=O)=CC2)CC1)C=3N(C)C=CC3
• Target: HDAC
• Solubility: DMSO:247.5 mg/mL (826.87 mM)

Bioactivity

• Target IC50:
  HDAC6:36 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acyl, accumulation, isoform, MPI_5a, inhibit, Inhibitor, HDAC, HDAC6, Histone deacetylases, selective, tubulin

Compound Identifiers

PubChem CID

49831258