MPI-0479605

SKU: orb1305718

Description

MPI-0479605

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1246529-32-7
• MW: 407.51
• Purity: 97.59%
• Formula: C₂₂H₂₉N₇O
• SMILES: Cl.Cc1cc(ccc1Nc1nc(NC2CCCCC2)c2nc[nH]c2n1)N1CCOCC1
• Target: Apoptosis,Kinesin
• Solubility: Ethanol:2 mg/mL (4.91 mM);DMSO:1 mg/mL (2.45 mM)

Bioactivity

• Target IC50:
  FAK1:2.7 μM|ERK2:3.9 μM|FLT3:0.08 μM|STK33:1.1 μM|JNK1:0.11 μM Insulin receptor:0.38 μM|Mps1:1.8 nM|ALK:0.26 μM|PLK4:3.3 μM|FER:0.59 μM|B-Raf:3.2 μM
• In Vivo:
  In a panel of tumor cell lines, MPI-0479605 caused a significant reduction in cell viability with a GI50 ranging from 30 to 100 nM. In addition, MPI-0479605 induced cell growth arrest and ultimately cell death through apoptosis or mitotic damage. chromosome segregation defects and alloploidy.
• In Vitro:
  In a panel of tumor cell lines, MPI-0479605 caused a significant reduction in cell viability with a GI50 ranging from 30 to 100 nM. In addition, MPI-0479605 induced cell growth arrest and ultimately cell death through apoptosis or mitotic damage. chromosome segregation defects and alloploidy.
• Cell Research:
  Cells are treated for 3 or 7 days with various concentration of MPI-0479605 an the GI50 is determined. Cell viability is measured with CellTiter-Glo. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Monopolar spindle 1, MPI0479605, MPI-0479605, MPI 0479605, Mps1, Apoptosis

Compound Identifiers

PubChem CID

91895225