MP7

SKU: orb1309275

Description

MP7 is a potent and selective small molecule inhibitor targeting phosphoinositide-dependent kinase-1 (PDK1). It is a valuable research tool for studying PI3K/AKT signaling pathways in cancer biology, applicable in both in vitro cellular assays and in vivo model systems.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1001409-50-2
• MW: 516.5
• Purity: 99.84%
• Formula: C₂₈H₂₂F₂N₄O₄
• SMILES: Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F
• Target: PDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.87 mM);DMSO:≥ 100 mg/mL (193.61 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  MP7 are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MP7, MP-7, MP 7, PDK1, PDK-1, PDK1 inhibitor, kinase-1, Inhibitor, inhibit, phosphoinositide-dependent

Compound Identifiers

PubChem CID

49766501