MP1202

SKU: orb3136054

Description

MP1202 is a dual agonist for MOR and KOR, with EC50 values of 0.32 μM for mMOR-1 and 0.13 μM for mKOR-1. It exhibits functional selectivity by reducing β-arrestin1/2 recruitment in hMOR and hKOR while significantly activating G protein and Gα subtypes. In opioid receptor subtype knockout mouse models, MP1202 demonstrates potent antinociceptive effects without typical opioid side effects, albeit it induces conditioned place preference and aversion behaviors, indicating potential for analgesic research.

Key Properties

• CAS Number: 2578974-82-8
• MW: 556.44
• Formula: C₂₇H₂₉IN₂O₃
• SMILES: N(C(=O)C1=CC(I)=CC=C1)[C@H]2[C@]3([C@]45C=6C(O3)=C(O)C=CC6C[C@]([C@@]4(CC2)[H])(N(CC7CC7)CC5)[H])[H]
• Target: Arrestin,Opioid Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Arrestin,Opioid Receptor