Mouse TGF-Beta 1 / TGFB1 Protein, Tag Free (MALS verified)

SKU: orb3032192

Description

Transforming Growth Factor beta 1 (TGF β 1/TGFB1 Protein) is a multifunctional cytokine synthesized by almost all cells. It demonstrates significant amino acid sequence stability across diverse species, underscoring its conserved function throughout evolution. TGF β 1/TGFB1 Protein is secreted as an inactive peptide, forming a 'latent complex' composed of a mature TGFB1 dimer non-covalently bound to its latency-associated peptide (LAP), which subsequently links to latent TGFB-binding proteins (LTBPs). The activated TGF β 1/TGFB1 Protein binds to ubiquitously expressed cell-surface transmembrane serine/threonine kinase receptors, specifically the type I (TGFBRI) and type II (TGFBRII) receptors, with a high binding ability to TGFbRII. This receptor engagement regulates various critical cellular processes including proliferation, growth, differentiation, and cell movement. Moreover, TGF β 1/TGFB1 Protein exerts immunomodulatory and profibrogenic effects, acting both locally and systemically, and plays a pivotal role in development, fibrosis, and cancer.

Images & Validation

• Application Notes:
  This protein carries no "tag". The protein has a calculated MW of 41.3 kDa. The protein migrates as 13-14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Key Properties

• Expression System: CHO
• Target: TGF-beta 1
• Reactivity: Mouse
• Tag: Native
• Molecular Weight: 41.3 kDa
• Expression Region: Leu 30 - Ser 390
• Purity: 90%
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
• Form/Appearance: Powder
• Buffer/Preservatives: 50 mM HAC, pH 3.0
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TGF-beta 1