Mouse MERTK / Mer Protein

SKU: orb1496231

Description

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Research Area

Signal Transduction

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Source: Mouse MERTK, His Tag (orb1496231) is expressed from human 293 cells (HEK293). It contains AA Gly 19 - Met 497 (Accession # Q60805-1).
• Expression System: HEK293
• Target: MERTK
• Reactivity: Mouse
• Tag: C-10×His
• Molecular Weight: 54.2 kDa
• Expression Region: Gly 19 - Met 497
• Purity: 95%
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -70℃
• Form/Appearance: Liquid
• Buffer/Preservatives: PBS, pH7.4
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Alternative Names

MERTK,Mer

Quick Database Links

Gene Symbol

MERTK

UniProt

Q60805

RefSeq:Q60805