Motolimod

SKU: orb1222991

Description

Motolimod, also known as VTX-2337, is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.

Key Properties

• CAS Number: 926927-61-9
• MW: 458.6
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₄N₄O₂
• SMILES: CCCN(CCC)C(=O)C1=Cc2c(cc(cc2)c2ccc(cc2)C(=O)N2CCCC2)N=C(N)C1
• Target: GluR
• Solubility: DMSO : 50 mg/mL. 109.03 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VTX-2337 | VTX 2337 | VTX2337 | Motolimod

Quick Database Links

Gene Symbol

GluR