Moslosooflavone

SKU: orb1301504

Description

Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) is a bioactive flavonoid with demonstrated anti-hypoxic activity, significantly extending survival in hypoxic mouse models. Its mechanism involves the inhibition of NF-κB transcriptional activity in stimulated RAW 264.7 macrophages, making it a useful research tool for studying hypoxia and inflammation pathways.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3570-62-5
• MW: 298.29
• Purity: 99.78% (May vary between batches)
• Formula: C₁₇H₁₄O₅
• SMILES: COc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1OC
• Target: Reactive Oxygen Species,NF-κB,ROS
• Solubility: DMSO:10 mg/mL (33.52 mM)

Bioactivity

• In Vivo:
  5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice.
• In Vitro:
  5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells.
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• Animal Research:
  The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-hypoxia, anti-inflammatory, 5-hydroxy-7,8-dimethoxyflavone, Moslosooflavone, Inhibitor, flavonoid, NFkB, NFκB, NF-kB, NF-κB, inhibit, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

188316