Morroniside

SKU: orb1222457

Description

Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhibiting hyperglycemia and oxidative stress. Morroniside can notably protect the brain from damage induced by focal cerebral ischemia which might be related to morroniside antioxidant and anti-apoptotic properties in the brain.

Key Properties

• CAS Number: 25406-64-8
• MW: 406.38
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₆O₁₁
• SMILES: C[C@H]1[C@@H]2[C@H](CC(O1)O)C(=CO[C@H]2O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)C(=O)OC
• Target: Antioxidant
• Solubility: DMSO : 125 mg/mL 307.59 mM

Bioactivity

• In Vivo:
  Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase 3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl 2 is significantly downregulated. The expression of active caspase 3 and Bax is significantly downregulated by Morroniside treatment in a dose dependent manner, while the expression of Bcl 2 is significantly upregulated. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antioxidant