Moroxydine hydrochloride

SKU: orb1225324

Description

Moroxydine hydrochloride is a synthetic antiviral drug chemically belonging to the series of the heterocyclic biguanidines. Structurally moroxydine is a heterocyclic biguanidine. It possesses antiviral activity and is of value in the prevention and treatment of influenza. Although its mechanism of action is not fully known the effects seem to be due to an influence on the virus host-cell system.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3160-91-6
• MW: 207.66
• Purity: >98% (HPLC)
• Formula: C₆H₁₃N₅O·HCl
• SMILES: N1(C(=N)NC(N)=N)CCOCC1
• Target: Antiviral
• Solubility: Water: 42 mg/mL (202.25 mM); DMSO: 42 mg/mL (202.25 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: GCRV infected CIK cells. Concentration: 1.0, 2.5, 6.3, 15.9, 39.8, 100 μg/mL. Incubation time: 24, 48, 72, 96 h. Result: Showed concentration- and time-dependent induction of cell viability. Apoptosis Analysis Cell line: GCRV infected CIK cells. Concentration: 40 μg/mL. Incubation time: 48, 96 h. Result: Could block the virus-induced CPE and cell death within 96 h. Western blot analysis. Cell line: GCRV infected CIK cells. Concentration: 40 μg/mL. Incubation time: 12, 24, 48 h. Result: Completely avoided the apoptosis and also significantly inhibited the caspase 3 activity, Bax expression and down-regulated Bcl-2 at 48 h, compared with GCRV infection group.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABOB

Quick Database Links

Gene Symbol

Antiviral