Moracin C

SKU: orb2900235

Description

Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.

Key Properties

• CAS Number: 69120-06-5
• MW: 310.34
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈O₄
• SMILES: CC(C)=CCc1c(O)cc(cc1O)-c1cc2ccc(O)cc2o1
• Target: ROS
• Solubility: In Vitro: DMSO : 250 mg/mL (805.57 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Animal model: Mice (PK Assay). Dosage: 100 mg/kg. Administration: Oral gavage. Result: Pharmacokinetic profile of Moracin C.
• In Vitro:
  RT-PCR Cell line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM. Incubation time: 2 h. Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western blot analysis. Cell line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM. Incubation time: 2 h. Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS