Monomethyl lithospermate

• Catalog Number: orb1683248
• Category: Small Molecules
• Description: Monomethyl lithospermate
• CAS Number: 933054-33-2
• Purity: 98%
• MW: 552.48
• SMILES: C(OC)(=O)[C@H]1C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(O)C=CC2/C=C/C(O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O)=O
• Formula: C₂₈H₂₄O₁₂
• Biological Activity: Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.