Monacolin J

SKU: orb1309400

Description

Monacolin J, also known as Antibiotic MB 530A, is a potent inhibitor of cholesterol biosynthesis. This compound is widely used in biochemical research to study lipid metabolism and evaluate HMG-CoA reductase inhibition in both in vitro enzymatic assays and in vivo metabolic studies.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 79952-42-4
• MW: 320.42
• Purity: 98.87% (May vary between batches)
• Formula: C₁₉H₂₈O₄
• SMILES: C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@@]3(C(C=C[C@@H]2C)=C[C@H](C)C[C@@H]3O)[H]
• Target: Autophagy,HMG-CoA Reductase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.24 mM);DMSO:55 mg/mL (171.65 mM)

Bioactivity

• In Vitro:
  Monacolin J is a cholesterol biosynthesis inhibitor, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Monacolin J, Lovastatin diol lactone, inhibit, Inhibitor, HMG-CoA reductase, HMGCoA Reductase, HMGCoAReductase, HMGCR, HMG-CoA Reductase (HMGCR), Autophagy, Antibiotic MB 530A

Compound Identifiers

PubChem CID

9905162