Mometasone furoate

SKU: orb1308297

Description

Mometasone furoate

Research Area

Metabolism Research

Key Properties

• CAS Number: 83919-23-7
• MW: 521.43
• Purity: 99.56%
• Formula: C₂₇H₃₀Cl₂O₆
• SMILES: O(C(=O)C1=CC=CO1)[C@@]2(C(CCl)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](Cl)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]
• Target: Glucocorticoid Receptor
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:45 mg/mL (86.3 mM)

Bioactivity

• In Vivo:
  Mometasone furoate effectively inhibits the production of cytokines, including interleukin (IL)-4, IL-5, and interferon-γ, in human CD4+ T cells stimulated by anti-CD3. It also efficiently suppresses the activation of Th cells, including type 2 helper T (Th2) cells, in draining lymph nodes, leading to the suppression of the IgE response.
• In Vitro:
  Both 0.02% Mometasone furoate and 0.1% Fluticasone propionate significantly suppress the increase in antigen-induced nasal rubbing even six hours after topical application, demonstrating their lasting effects. Mometasone furoate reduces nasal rubbing in rats and, at the highest tested dose in mice (3mg/kg), inhibits the increased sensitivity to aerosolized acetylcholine. The compound dose-dependently suppresses the elevation of eosinophil counts in the bronchoalveolar lavage fluid and lung tissue of mice challenged with sensitizing ovalbumin. Furthermore, a dosage of 33 mg/kg Mometasone furoate lowers the percentage of CD44+ T helper cells (activated/memory cells) to levels observed in mice not challenged with sensitizing ovalbumin, indicating its immunomodulatory potential.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anti-inflammatory, asthma, inhibit, Inhibitor, Mometasone furoate, Mometasone Furoate, GlucocorticoidReceptor, Glucocorticoid Receptor, eczema, hay fever, Sch 32088, Sch32088, Sch-32088, skin corticosteroid, steroid

Compound Identifiers

PubChem CID

441336