MOMBA

SKU: orb1979918

Description

MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrates selective inactivity towards wild-type hFFA2, hFFA3, and mouse FFA2 receptors. It efficiently inhibits forskolin-induced cAMP levels in cells equipped with the hFFA2-DREADD receptor, exhibiting enhanced potency and comparable efficacy to Sorbic acid. In transgenic mice containing the hFFA2-DREADD gene, MOMBA administration notably slows gut transit and facilitates a concentration-dependent enhancement of GLP-1 secretion from colonic crypts, all while being orally bioavailable.

Key Properties

• CAS Number: 6880-04-2
• MW: 166.17
• Formula: C₉H₁₀O₃
• SMILES: COC1=C(C)C=C(C=C1)C(O)=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

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Gene Symbol

Others