Molsidomine

SKU: orb1310929

Description

Molsidomine is an oral, long-acting vasodilator prodrug. Its hepatic metabolite, linsidomine, decomposes to release nitric oxide (NO), the active vasodilating agent. This compound is used in cardiovascular research, including studies of vascular tone and endothelial function in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 25717-80-0
• MW: 242.23
• Purity: >99.99% (May vary between batches)
• Formula: C₉H₁₄N₄O₄
• SMILES: [N-](C(OCC)=O)C1=C[N+](=NO1)N2CCOCC2
• Target: Drug Metabolite,NOD
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.26 mM);DMSO:45 mg/mL (185.77 mM);H2O:9 mg/mL (37.15 mM);Ethanol:21 mg/mL (86.69 mM)

Bioactivity

• In Vivo:
  Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Morsydomine, inhibit, Molsidomine, NOD, Inhibitor, Corvaton, Drug Metabolite, SIN 10, SIN10, SIN-10

Compound Identifiers

PubChem CID

4238