Molnupiravir

SKU: orb1689082

Description

Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the antiviral ribonucleoside EIDD-1931. It is a broad-spectrum antiviral research compound active against SARS-CoV-2, influenza, and other coronaviruses in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2492423-29-5
• MW: 329.31
• Purity: 99.81% (May vary between batches)
• Formula: C₁₃H₁₉N₃O₇
• SMILES: CC(C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc\c(=N/O)[nH]c1=O
• Target: Influenza Virus,SARS-CoV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.07 mM);DMSO:257.5 mg/mL (781.94 mM)

Bioactivity

• In Vivo:
  METHODS: Molnupiravir (MK-4482) (EIDD-2801) (50, 150, or 500 mg/kg, orally, every 12 hours) was used to prophylactically treat mice infected with SARS-CoV and observe its effects in mice. RESULTS Molnupiravir has potent antiviral activity and is able to prevent SARS-CoV replication and disease.
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• In Vitro:
  METHODS: RD, Huh7, and Vero cells were treated with Molnupiravir (MK-4482) (EIDD-2801) (1, 10, 100 μM) for cytopathic effect (CPE) protection assay. RESULTS EIDD-2801 showed stable CPE protection potential in a dose-dependent manner in multiple cell lines infected with EV-A71 virus; the value against EV-A71 virus was 70.12±4.40μM in RD cells; 88.52±3.18μM in Vero cells, and 35.64±0.47μM in Huh7 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2349386-89-4, Molnupiravir, MK4482, MK-4482, MK 4482, InfluenzaVirus, Influenza virus, Influenza Virus, Lagevrio, EIDD 2801, EIDD2801, EIDD-2801, SARSCoV, SARS-CoV

Compound Identifiers

PubChem CID

145996610