Mollugin

SKU: orb1303924

Description

Mollugin (Rubimaillin) is a natural small molecule with research applications as a JAK2 inhibitor, suppressing inflammation via the JAK-STAT and NF-κB pathways. It demonstrates potential in oncology research, including OSCC and HER2-overexpressing cancers, and in bone disorder models by upregulating Nrf2/HO-1. Studies support its use in both in vitro and in vivo experimental contexts.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 55481-88-4
• MW: 284.31
• Purity: 99.87% (May vary between batches)
• Formula: C₁₇H₁₆O₄
• SMILES: COC(=O)c1c(O)c2ccccc2c2OC(C)(C)C=Cc12
• Target: NF-κB,Apoptosis,ROS,HER,JAK,c-Myc,Reactive Oxygen Species,VEGFR
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Acetone:Soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM);DMSO:31.56 mg/mL (111.01 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ROS, Rubimaillin, VEGFR, Vascular endothelial growth factor receptor, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, Mollugin, inhibit, JAK2, Myc, Inhibitor, Liver cancer, Hep3B, HeLa, HEK293, HepG2 cells, HER2, H22-tumor, DNA damage, c-Myc, antitumor, anti-hepatocellular, Apoptosis

Compound Identifiers

PubChem CID

124219