Molidustat

SKU: orb1701289

Description

Molidustat (BAY 85-3934) is a small molecule hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. It promotes endogenous erythropoietin synthesis and erythropoiesis, making it a valuable research tool for studying anemia, hypoxia signaling, and renal disease in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1154028-82-6
• MW: 314.3
• Purity: 99.79% (May vary between batches)
• Formula: C₁₃H₁₄N₈O₂
• SMILES: O=c1c(c[nH]n1-c1cc(ncn1)N1CCOCC1)-n1ccnn1
• Target: HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:11 mg/mL (35 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.59 mM)

Bioactivity

• Target IC50:
  PHD3:450 nM|PHD1:480 nM|PHD2:280 nM
• In Vivo:
  In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects.
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• In Vitro:
  In vitro, Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIF ProlylHydroxylase, HIF, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF-PH, HIFProlylHydroxylase, HIFs, Inhibitor, Hypoxia-inducible factors, inhibit, Molidustat, BAY 85-3934, PHD2, PHD1, PHD3

Compound Identifiers

PubChem CID

59603622