Molibresib besylate

SKU: orb1709549

Description

Molibresib besylate (GSK525762C) is a potent and selective BET bromodomain inhibitor studied for refractory hematologic cancers. It induces reactive oxygen species (ROS) and ATM activation, demonstrating antitumor activity in both in vitro and in vivo preclinical models.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation

Key Properties

• CAS Number: 1895049-20-3
• MW: 582.07
• Purity: 99.64%
• Formula: C₂₈H₂₈ClN₅O₅S
• SMILES: S(=O)(=O)(O)C1=CC=CC=C1.O(C)C=1C=C2C(N3C([C@H](CC(NCC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)=CC1
• Target: ROS,Epigenetic Reader Domain
• Solubility: DMSO:20 mg/mL (34.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.44 mM)

Bioactivity

• Target IC50:
  BET:32.5-42.5 nM

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BET, I-BET 762 besylate, GSK 525762C, EpigeneticReaderDomain, Epigenetic Reader Domain, Molibresib besylate, ROS

Compound Identifiers

PubChem CID

133082230